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AMITRIPTYLINE is used for treating depression.

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Amitriptyline is used for: The relief of depression. It may also be used to treat chronic pain and other conditions as determined by your doctor. Amitriptyline is a tricyclic antidepressant. How tricyclic antidepressants improve depression symptoms is not fully understood. They are thought to increase the activity of certain chemicals in the brain (norepinephrine, serotonin), which help improve mood. Do NOT use Amitriptyline if: you are allergic to any ingredient in Amitriptyline you are currently taking or have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine, selegiline) within the last 14 days you are taking antihistamines (eg, diphenhydramine), cisapride, dofetilide, droperidol, fluoroquinolones (eg, ciprofloxacin), ketolides (eg, telithromycin) macrolides (eg, erythromycin), mibefradil, or pimozide you are recovering from a heart attack Contact your doctor or health care provider right away if any of these apply to you. Before using Amitriptyline : Some medical conditions may interact with Amitriptyline. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of mental illness (eg, bipolar disorder, mania, manic-depression), or have considered or attempted suicide if you have alcoholism or regularly consume 3 or more alcoholic beverages per day if you have glaucoma, an irregular heartbeat, heart disease, chest pain, liver disease, prostate problems, thyroid disease, or are unable to urinate (urinary retention) if you have a history of seizures, epilepsy, or porphyria Some MEDICINES MAY INTERACT with Amitriptyline. Tell your health care provider if you are taking any other medicines, especially any of the following: MAO inhibitors (eg, phenelzine, selegiline) because they can cause serious, sometimes life-threatening, reactions. Do NOT take MAO inhibitors with, or within 2 weeks of taking, Amitriptyline Anticholinergics (eg, scopolamine), bupropion, cimetidine, fluconazole, phenothiazines (eg, chlorpromazine), SSRIs (eg, fluoxetine), terbinafine, or valproic acid because side effects such as blurred vision, difficult urination, drowsiness or sedation, dry mouth, or lightheadedness may occur Antihistamines (eg, diphenhydramine), cisapride, dofetilide, droperidol, fluoroquinolones (eg, ciprofloxacin), ketolides (eg, telithromycin), macrolides (eg, erythromycin), mibefradil, pimozide, or streptogramins (eg, quinupristin/dalfopristin) because serious side effects on the heart (eg, racing heartbeat, dizziness, fainting, life-threatening abnormal heartbeat leading to unconsciousness, and lack of heartbeat, may be increased by Amitriptyline Carbamazepine, thyroid medicines (eg, levothyroxine), or stimulants (eg, albuterol, pseudoephedrine) because their side effects may be increased by Amitriptyline Warfarin because side effects such as serious bleeding may be increased by Amitriptyline Clonidine, guanethidine, or guanfacine because the effectiveness of these medicines may be decreased This may not be a complete list of all interactions that may occur. Ask your health care provider if Amitriptyline may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. How to use Amitriptyline : Use Amitriptyline as directed by your doctor. Check the label on the medicine for exact dosing instructions. Amitriptyline comes with an additional patient information sheet called a Medication Guide. Read it carefully and reread it each time you get Amitriptyline refilled. Amitriptyline may be taken with food or on an empty stomach. Avoid eating or drinking grapefruit juice while taking Amitriptyline. Amitriptyline may take up to 30 days to control symptoms of depression. Continue to use Amitriptyline even if you feel well. Do not miss any doses. If you miss a dose of Amitriptyline , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Amitriptyline.

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